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1

DNA strand breaking by the carbon-centered radical generated from 4-(hydroxymethyl) benzenediazonium salt, a carcinogen in mushroom Agaricus bisporus

Kazuyuki Hiramoto, Masae Kaku, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Chemico-Biological Interactions

Year:

1995

Language:

english

File:

PDF, 985 KB

english, 1995

2

Conversion of Nitroxide Radicals by Phenolic and Thiol Antioxidants

Hiramoto, Kazuyuki, Ojima, Natsuko, Kikugawa, Kiyomi

Journal:

Free Radical Research

Year:

1997

Language:

english

File:

PDF, 566 KB

english, 1997

3

Release of nitric oxide together with carbon-centered radicals from N-nitrosamines by ultraviolet light irradiation

Hiramoto, Kazuyuki, Ohkawa, Takumi, Kikugawa, Kiyomi

Journal:

Free Radical Research

Year:

2001

Language:

english

File:

PDF, 741 KB

english, 2001

4

Proteome analysis of new antimalarial endoperoxide againstPlasmodium falciparum

Nagwa S. M. Aly, Akiko Hiramoto, Hitomi Sanai, Osamu Hiraoka, Kazuyuki Hiramoto, Hiroyuki Kataoka, Jin-Ming Wu, Araki Masuyama, Masatomo Nojima, Satoru Kawai, Hye-Sook Kim, Yusuke Wataya

Journal:

Parasitology Research

Year:

2007

Language:

english

File:

PDF, 173 KB

english, 2007

5

GENERATION OF INTRACELLULAR ACTIVE OXYGENS IN MOUSE FM3A CELLS BY 3-HYDROXYAMINO-1-METHYL-5H-PYRIDO[4,3-b]INDOLE, THE ACTIVATED TRP-P-2

Yusuke Wataya, Kazuko Yamane, Kazuyuki Hiramoto, Yasuharu Ohtsuka, Yuko Okubata, Kazuo Negishi, Hikoya Hayatsu

Journal:

Year:

1988

File:

PDF, 169 KB

1988

6

Induction of DNA Recombination by Activated 3-Amino-1-methyl-5H-pyrido[4,3-b]indole

Kazuyuki Hiramoto, Shin-ichi Kanamitsu, Kazuo Negishi, Hideo Ikeda, Hikoya Hayatsu

Journal:

Year:

1995

File:

PDF, 307 KB

1995

7

DNA Single Strand Breaks by Aromatic Nitroso Compounds in the Presence of Thiols

Ojima, Natsuko, Kikugawa, Kiyomi, Hiramoto, Kazuyuki

Journal:

Free Radical Research

Year:

1997

Language:

english

File:

PDF, 784 KB

english, 1997

8

Prevention of the formation of mutagenic and/or carcinogenic heterocyclic amines by food factors

Kiyomi Kikugawa, Kazuyuki Hiramoto, Tetsuta Kato

Journal:

Year:

2000

Language:

english

File:

PDF, 39 KB

english, 2000

9

DNA strand breakage by hydroxyphenyl radicals generated from mutagenic diazoquinone compounds

Tetsuta Kato, Kazuhiro Kojima, Kazuyuki Hiramoto, Kiyomi Kikugawa

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

10

Generation of DNA-breaking activity in the Maillard reaction of glucose-amino acid mixtures in a solid system

Kazuyuki Hiramoto, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1993

Language:

english

File:

PDF, 618 KB

english, 1993

11

Mechanisms of the DNA breaking activity of mutagenic 5-diazouracil

Kazuyuki Hiramoto, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 933 KB

english, 1994

12

Possible occurrence of new mutagens with the DNA breaking activity in coffee

Tetsuta Kato, Kazuyuki Hiramoto, Kiyomi Kikugawa

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

13

Inhibitory effect of myoglobin and hemoglobin on the direct-acting mutagenicity of protein pyrolysate heterocyclic amine derivatives

Sakae Arimoto, Yoshiko Ohara, Kazuyuki Hiramoto, Hikoya Hayatsu

Journal:

Mutation Research Letters

Year:

1987

Language:

english

File:

PDF, 379 KB

english, 1987

14

Vasorelaxant effect of olprinone, an inhibitor of phosphodiesterase 3, on mesenteric small artery and vein of rabbits

Seigo Fujimoto, Masuo Ohashi, Akinori Hiramoto, Yuusuke Inoue, Kazuyuki Nagai, Hiroaki Shiokawa, Takeo Itoh

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 126 KB

english, 1998

15

P XVII B.22 - P XVII B.22 DNA strand breaking activity and mutagenicity of a Maillard reaction product, 2,3-dihydro-3,5-dihydroxy-6-methyl-4h-pyran-4-one

Kazuyuki Hiramoto, Akiko Nasuhara, Kae Michikoshi, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 114 KB

english, 1997

16

DNA strand break by 2,5-dimethyl-4-hydroxy-3(2 H)-furanone, a fragnant compound in various foodstuffs

Kazuyuki Hiramoto, Reiko Aso-o, Hiromi Ni-iyama, Shiori Hikage, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1996

Language:

english

File:

PDF, 544 KB

english, 1996

17

DNA breaking activity and mutagenicity of soy sauce: characterization of the active components and identification of 4-hydroxy-5-methyl-3(2H)-furanone

Kazuyuki Hiramoto, Kaoru Sekiguchi, Kaoru Ayuha, Reiko Aso-o, Natsuko Moriya, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1996

Language:

english

File:

PDF, 932 KB

english, 1996

18

Standardization of Nitric Oxide Aqueous Solutions by Modified Saltzman Method

Takumi Ohkawa, Kazuyuki Hiramoto, Kiyomi Kikugawa

Journal:

Year:

2001

Language:

english

File:

PDF, 235 KB

english, 2001

19

β-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid

Kiyomi Kikugawa, Kazuyuki Hiramoto, Susumu Tomiyama, Yoshiko Asano

Journal:

Year:

1997

Language:

english

File:

PDF, 421 KB

english, 1997

20

DNA strand-breaking activity and mutagenicity of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP), a Maillard reaction product of glucose and glycine

Kazuyuki Hiramoto, Akiko Nasuhara, Kae Michikoshi, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1997

Language:

english

File:

PDF, 367 KB

english, 1997

21

Absorption and induction of micronucleated peripheral reticulocytes in mice after oral administration of fragrant hydroxyfuranones generated in the Maillard reaction

Kazuyuki Hiramoto, Tetsuta Kato, Yasuhiro Takahashi, Kazunori Yugi, Kiyomi Kikugawa

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1998

Language:

english

File:

PDF, 153 KB

english, 1998

22

Identification of hydroxyhydroquinone in coffee as a generator of reactive oxygen species that break DNA single strands

Kazuyuki Hiramoto, Xianghong Li, Mitsumasa Makimoto, Tetsuta Kato, Kiyomi Kikugawa

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1998

Language:

english

File:

PDF, 319 KB

english, 1998

23

Participation of the pyrazine cation radical in the formation of mutagens in the reaction of glucose/glycine/creatinine

Kiyomi Kikugawa, Tetsuta Kato, Kazuyuki Hiramoto, Chiharu Takada, Miho Tanaka, Yoshiko Maeda, Tomokazu Ishihara

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1999

Language:

english

File:

PDF, 305 KB

english, 1999

24

Effect of food reductones on the generation of the pyrazine cation radical and on the formation of the mutagens in the reaction of glucose, glycine and creatinine

Kiyomi Kikugawa, Kazuyuki Hiramoto, Tetsuta Kato, Hirokazu Yanagawa

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2000

Language:

english

File:

PDF, 243 KB

english, 2000

25

DNA strand cleavage by tumor-inhibiting antibiotic 6-diazo-5-oxo-l-norleucine

Kazuyuki Hiramoto, Tomofumi Fujino, Kiyomi Kikugawa

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1996

Language:

english

File:

PDF, 407 KB

english, 1996

26

Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol

Akira Sato, Akiko Hiramoto, Masayuki Morita, Masahiro Matsumoto, Yuka Komich, Yukari Nakase, Natsuki Tanigawa, Osamu Hiraoka, Kazuyuki Hiramoto, Hikoya Hayatsu, Kazutaka Higaki, Satoru Kawai, Araki Ma

Journal:

Parasitology International

Year:

2011

Language:

english

File:

PDF, 443 KB

english, 2011

27

Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives

Akira Sato, Satoru Kawai, Akiko Hiramoto, Masayuki Morita, Natsuki Tanigawa, Yukari Nakase, Yuka Komichi, Masahiro Matsumoto, Osamu Hiraoka, Kazuyuki Hiramoto, Hidekazu Tokuhara, Araki Masuyama, Masat

Journal:

Parasitology International

Year:

2011

Language:

english

File:

PDF, 588 KB

english, 2011

28

DNA Breaking by Maillard Products of Glucose-Amino Acid Mixtures Formed in an Aqueous System

Hiramoto, Kazuyuki, Kido, Kaori, Kikugawa, Kiyomi

Journal:

Journal of Agricultural and Food Chemistry

Year:

1994

Language:

english

File:

PDF, 2.62 MB

english, 1994

29

Dna Breaking Activity of the Carbon-Centered Radical Generated from 2,2′-Azobis(2-Amidinopropane) Hydrochloride (AAPH)

Hiramoto, Kazuyuki, Johkoh, Hitoshi, Sako, Ken-Ichi, Kikugawa, Kiyomi

Journal:

Free Radical Research

Year:

1993

Language:

english

File:

PDF, 607 KB

english, 1993

30

Protective Effect of Supplementation of Fish Oil with High n −3 Polyunsaturated Fatty Acids against Oxidative Stress-Induced DNA Damage of Rat Liver in Vivo

Kikugawa, Kiyomi, Yasuhara, Yoshinobu, Ando, Ken, Koyama, Keiko, Hiramoto, Kazuyuki, Suzuki, Masao

Journal:

Journal of Agricultural and Food Chemistry

Year:

2003

Language:

english

File:

PDF, 106 KB

english, 2003

31

DNA Base and Deoxyribose Modification by the Carbon-Centered Radical Generated from 4-(Hydroxymethyl)benzenediazonium Salt, a Carcinogen in Mushroom

Hiramoto, Kazuyuki, Kaku, Masae, Sueyoshi, Atsushi, Fujise, Mizuko, Kikugawa, Kiyomi

Journal:

Chemical Research in Toxicology

Year:

1995

Language:

english

File:

PDF, 857 KB

english, 1995

32

Effect of Food Reductones, 2,5-Dimethyl-4-hydroxy-3(2 H )-furanone (DMHF) and Hydroxyhydroquinone (HHQ), on Lipid Peroxidation and Type IV and I Allergy Responses of Mouse

Mi, Hongbin, Hiramoto, Kazuyuki, Kujirai, Kaori, Ando, Ken, Ikarashi, Yoshiaki, Kikugawa, Kiyomi

Journal:

Journal of Agricultural and Food Chemistry

Year:

2001

Language:

english

File:

PDF, 115 KB

english, 2001

33

β -Carotene generates thiobarbituric acid-reactive substances by interaction with nitrogen dioxide in air

Kikugawa, Kiyomi, Hiramoto, Kazuyuki, Hirama, Akiko

Journal:

Free Radical Research

Year:

1999

Language:

english

File:

PDF, 534 KB

english, 1999

34

Effect of β-carotene on the transformation of tyrosine by nitrogen dioxide and peroxynitrous acid

Kikugawa, Kiyomi, Hiramoto, Kazuyuki, Tomiyama, Susumu, Nakauchi, Kazuya

Journal:

Free Radical Research

Year:

1999

Language:

english

File:

PDF, 518 KB

english, 1999

35

Appearance of Electron Spin Resonance Signals in the Interaction of Dithiocarbamate-Fe(II) with Nitrogen Dioxide and Nitrite

Hiramoto, Kazuyuki, Tomiyama, Susumu, Kikugawa, Kiyomi

Journal:

Free Radical Research

Year:

1997

Language:

english

File:

PDF, 426 KB

english, 1997

36

Effective inhibition by β -carotene of cellular DNA breaking induced by peroxynitrous acid

Hiramoto, Kazuyuki, Tomiyama, Susumu, Kikugawa, Kiyomi

Journal:

Free Radical Research

Year:

1999

Language:

english

File:

PDF, 499 KB

english, 1999

37

Enhancement of Nitrogen Dioxide-Induced Lipid Peroxidation and Dna Strand Breaking by Cysteine and Glutathione

Kikugawa, Kiyomi, Hiramoto, Kazuyuki, Okamoto, Yutaka, Hasegawa, Yo-Ko

Journal:

Free Radical Research

Year:

1994

Language:

english

File:

PDF, 679 KB

english, 1994

38

InGaN-Based Light-Emitting Diodes Fabricated on Nano Patterned Sapphire Substrates with Pillar Height of More than 600 nm by Nanoimprint Lithography

Okada, Narihito, Egami, Takuya, Miyoshi, Seita, Inomoto, Ryo, Yamane, Keisuke, Tadatomo, Kazuyuki, Nishimiya, Tomoyasu, Hiramoto, Michihiro, Motoyama, Shin-ichi

Journal:

Japanese Journal of Applied Physics

Year:

2013

Language:

english

File:

PDF, 809 KB

english, 2013

39

Formation of the mutagenic/carcinogenic imidazoquinoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants

Kato, Tetsuta, Harashima, Takehiro, Moriya, Natsumi, Kikugawa, Kiyomi, Hiramoto, Kazuyuki

Journal:

Year:

1996

Language:

english

File:

PDF, 741 KB

english, 1996

40

Superoxide dismutase-mediated reversible conversion of 3-hydroxyamino-l-methyl-5 H -pyrido(4,3- b ) indole, the N -hydroxy derivative of Trp-P-2, into its nitroso derivative

Hiramoto, Kazuyuki, Negishi, Kazuo, Namba, Tetsuto, Katsu, Takashi, Hayatsu, Hikoya

Journal:

Year:

1988

Language:

english

File:

PDF, 587 KB

english, 1988

41

Appearance of Esr Signals by the Reaction of 3,5-Dibromo-4-Nitrosobenzenesulfonate (Dbnbs) and Non-Radical Biological Components

Hiramoto, Kazuyuki, Hasegawa, Yohko, Kikugawa, Kiyomi

Journal:

Free Radical Research

Year:

1994

Language:

english

File:

PDF, 529 KB

english, 1994

42

Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor

Terajima, Masaomi, Kaneko-Kobayashi, Yoko, Nakamura, Naoto, Yuri, Masatoshi, Hiramoto, Masashi, Naitou, Masanori, Hattori, Kazuyuki, Yokota, Hiroyuki, Mizuhara, Hidekazu, Higashi, Yasuyuki

Journal:

European Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 6.10 MB

english, 2016

43

Effect of Plant Phenolics on the Formation of the Spin-Adduct of Hydroxyl Radical and the DNA Strand Breaking by Hydroxyl Radical.

HIRAMOTO, Kazuyuki, OJIMA, Natsuko, SAKO, Ken-ichi, KIKUGAWA, Kiyomi

Journal:

Biological & Pharmaceutical Bulletin

Year:

1996

File:

PDF, 985 KB

1996

44

Formation of Hydroxyfuranone and Hydroxypyranone Derivatives with DNA-Breaking Activity in the Maillard Reaction of Glucose and Albumin under Physiological Conditions.

HIRAMOTO, Kazuyuki, ISHIHARA, Akira, SAKUI, Norihiro, DAISHIMA, Shigeki, KIKUGAWA, Kiyomi

Journal:

Biological & Pharmaceutical Bulletin

Year:

1998

File:

PDF, 549 KB

1998

45

Is Nitrotyrosine Generated in Human Erythrocytes in Circulation?

KIKUGAWA, Kiyomi, NAKAUCHI, Kazuya, BEPPU, Masatoshi, HIRAMOTO, Kazuyuki, ANDO, Ken, HAYAKAWA, Makio

Journal:

Biological & Pharmaceutical Bulletin

Year:

2000

File:

PDF, 1.49 MB

2000

46

Effect of Supplementation of n-3 Polyunsaturated Fatty Acids on Oxidative Stress-Induced DNA Damage of Rat Hepatocytes

Kikugawa, Kiyomi, Yasuhara, Yoshinobu, Ando, Ken, Koyama, Keiko, Hiramoto, Kazuyuki, Suzuki, Masao

Journal:

Biological & Pharmaceutical Bulletin

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

47

Suppression of Free Radical-Induced DNA Strand Breaks by Linoleic Acid and Low Density Lipoprotein in Vitro

Hiramoto, Kazuyuki, Yasuhara, Yoshinobu, Sako, Ken-ichi, Aoki, Kazuhiro, Kikugawa, Kiyomi

Journal:

Biological & Pharmaceutical Bulletin

Year:

2003

Language:

english

File:

PDF, 123 KB

english, 2003

48

Is Nitric Oxide (NO) an Antioxidant or a Prooxidant for Lipid Peroxidation?

Hiramoto, Kazuyuki, Ohkawa, Takumi, Oikawa, Natsuki, Kikugawa, Kiyomi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2003

Language:

english

File:

PDF, 103 KB

english, 2003

49

Fragrant 4-Hydroxy-3(2H)-furanones Swiftly Scavenge Nitrous Acid Causing Concomitant Formation of the Components with Relatively Weak Mutagenicity

Kikugawa, Kiyomi, Hiramoto, Kazuyuki, Matsumoto, Hanami, Kato, Tetsuta

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2000

File:

PDF, 938 KB

2000

50

Mutagenicity of Cooked Hamburger is Reduced by Addition of Ascorbate and Erythorbate to Ground Beef.

Kato, Tetsuta, Hiramoto, Kazuyuki, Kikugawa, Kiyomi

Journal:

JOURNAL OF HEALTH SCIENCE

Year:

2000

File:

PDF, 562 KB

2000

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